Team 5

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Physiopathology of cardiac injuries and dysfunctions

Supervisors
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Régis GUIEU
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Franck THUNY

Team members


Our research projects focus on :
1/ characterizing the role of the adenosinergic system in the cardiovascular response to inflammation, extreme conditions (hyperbaria, dysoxia and ischemia) and anti-cancer therapies;
2/ characterize the mechanisms of heart failure in the context of immuno-induced myocarditis, septic heart disease and genetic cardiomyopathies.

Our objectives:

  • Propose new biomarkers, derived from the adenosinergic system, for screening and monitoring cardiovascular disease.
  • Understand cardiovascular adaptation to extreme conditions.
  • Identify innovative early biomarkers of cardiotoxicities induced by anti-cancer therapies.
  • Characterize the pathophysiological mechanisms of heart disease