Team 3
Endothelium, circulating cells
and vascular diseases
Supervisors
Laurence PANICOT-DUBOIS
Team members
Thrombosis and cancer
Christophe Dubois
Thrombosis is the leading cause of death in industrialized countries. The objective of this research theme is to characterize the role of circulating cells such as platelets, neutrophils, NETs and microparticles on the formation of thrombus associated (I) or not (II) with the development of cancer. To carry out these two projects, our approaches combine in vitro and in vivo studies facilitated by a close link with the Pivmi platform.
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Since its first clinical description in 1865 by Armand Trousseau, the association between thrombosis and cancer has been strongly documented. During the evolution of a cancer, a procoagulant/prothrombotic phenotype sets in, conferring many advantages to the cancer cell. Indeed, the activation of the coagulation cascade and the aggregation of platelets around the cancer cells protect them from the immune response, facilitate their circulation in the blood and their adhesion to metastasis sites. The objective of our study is to determine, in vitro and in vivo in relevant models, the role of platelets and microparticles derived from cancer cells in thrombosis, tumor development and metastasis formation.
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In recent years neutrophils and NETs (NeutrophilExtracellular Traps) have been described as important players in platelet activation and procoagulant platelet formation, thus participating in thrombus formation. The objective of this project is to identify the role played by endothelium, platelet-smoothing muscle cells and neutrophil/NETs in the cell signaling involved in thrombus formation in the micro and macro blood circulation. In particular, we determine whether NETs are formed in vivo and what their role in thrombus formation can be using different thrombosis models (Laser, Iron Chloride and DVT).