Team 1

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Micronutrients and metabolic diseases

Supervisors
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Jean François LANDRIER

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Emmanuelle REBOUL

Team members


Theme 1 : Lipid micronutrient and lipid metabolism: from food to lipoproteins

Emmanuelle Reboul

Our aim is to decipher the metabolism of lipid micronutrients and lipids, from food ingestion to the postprandial phase. The organ at the center of this process is the intestine.
We study the factors that can modulate luminal metabolism, transport across enterocytes, and secretion into chylomicrons of lipid micronutrients and lipids. These factors may be genetic or environmental (diet composition, bariatric surgery, etc).
Once secreted into chylomicrons, lipid micronutrients and lipids enter the bloodstream to reach their target tissues, such as adipose tissue. In this context, we investigate the effect of the diabetic metabolic environment on lipoprotein metabolism.

Theme 2 : Phenotypic and molecular effects of micronutrients on metabolic pathways in adipose tissue

Jean-François Landrier

We focus on a central organ in the development of metabolic pathologies: the adipose tissue. At this level, we study lipid micronutrient metabolism and the consequences of inadequate lipid micronutrient status on obesity and associated disorders such as metabolic inflammation, dyslipidemia and insulin resistance. We also study the effect of obesity or insulin resistance on micronutrient metabolism.
The impact of lipid micronutrient deficiencies is evaluated in adults, but also during the perinatal period.

Cross-cutting themes: from fork to bedside

The increase in the world population, combined with global warming, encourages us to develop sustainable nutritional solutions to achieve food security and ensure a healthy future for both people and planet.
We are therefore seeking to identify and optimize sources of micronutrients, from insects to widely consumed agricultural products (rapeseed, apples, tomatoes, etc.), in order to assess their benefits for metabolic health. These projects mobilize the different expertise of the team.

Sample projects

ANR Tomhealth
ANR Complete
Bio-Belief
(Re)generation fruit