Hypertension is the leading cause of cardiovascular disease and premature death worldwide. Kidney disease, ischemic heart disease and heart failure can alter baroreflex sensitivity, resulting in inappropriate sympathetic system activity. Our team is studying the molecular and cellular mechanisms leading to changes in baroreflex sensitivity in models of hypertension and cardiovascular disease.
We use functional characterization approaches to baroreceptor and baroreflex activity (patch clamp, ex vivo electrophysiology, blood pressure/heart rate telemetry) combined with transcriptomics and molecular biology/biochemistry techniques to identify new molecular players involved in the baroreflex. We are studying the function and modulation of these players in models of hypertension. This could help define new avenues for the treatment of hypertension and its complications.

Our current lines of research envisage:

Previous publications

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