Team 1 has just published 2 new articles
+ A Citrullus colocynthis fruit extract acutely enhances insulin-induced GLUT4 translocation and glucose uptake in adipocytes by increasing PKB phosphorylation.
Coloquinte is well known for its anti-diabetic effects in vivo, but the mechanisms responsible for these effects are poorly understood. Only a chronic beneficial effect on insulin production has been described. Our study shows for the first time an acute ‘insulin enhancer’ effect on insulin signaling and the glucose transporter GLUT4 in the adipocyte, a cell that plays an important role in carbohydrate homeostasis. The phytomicroconstituent ‘insulin enhancer’ of coloquinte, which probably contributes to its already observed anti-diabetic effect, could constitute a new therapy for the treatment of type 2 diabetes.
To read the full paper, head to the following link:
https://doi.org/10.1016/j.jep.2020.113772 SMASH
+ 2′,7′-dichlorofluorescin-based analysis of Fenton chemistry reveals auto-amplification of probe fluorescence and albumin as catalyst for the detection of hydrogen peroxide.
The 2′,7′-dichlorofluorescin (DCF) fluorophore probe is the world’s most widely used probe for measuring oxidative stress in cells. However, the precise molecules it detects are not clearly identified, especially in the cell. In this work, we have studied the reactivity of DCF in cells, but also outside cells, in order to better use it in future work.
To read the full paper, head to the following link:
https://doi.org/10.1042/BCJ20200602 SMASH
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